For follow-up discussion and general commentary on the topic. Comments are sorted chronologically.
15 And I will put enmity between thee and the woman, and between thy seed and her Seed; It shall bruise thy head, and thou shalt bruise His heel.” When we talk of seed we usually talk of a man's seed, but here God talks of a seed of a woman.
This is the first mention of the coming of a messiah. God is talking about the coming of Jesus Christ.