Genesis 4:17
ESV - 17 Cain knew his wife, and she conceived and bore Enoch. When he built a city, he called the name of the city after the name of his son, Enoch.
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Adam and Eve undoubtedly had many children during their long lives, with only a very few of them having their stories recounted, or even having them mentioned by name, in the Bible, because the lives of those children were not central to the history of human salvation that God intended the Bible to convey to us. Cain's wife would undoubtedly have been one of that large number of descendants, and Cain would have been related to her, either as a brother or as some other male relation. (Such close intermarriage had not yet been forbidden by God, owing (in my opinion) to both the "purity" of the gene pool at that time (even with the presence of sin in the world), and also the overriding need to populate the earth and subdue it, as God had previously commanded Adam and Eve (and, by extension, their descendants) to do (Genesis 1:28).)
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