Matthew 16:24 - 26
ESV - 24 Then Jesus told his disciples, "If anyone would come after me, let him deny himself and take up his cross and follow me. 25 For whoever would save his life will lose it, but whoever loses his life for my sake will find it.
For follow-up discussion and general commentary on the topic. Comments are sorted chronologically.
That is the beauty of following Christ ascended rather than following Christ's earthly ministry to Israel. Christ 'took up the cross' on our behalf. We only need to trust in what He accomplished and completed for us at Calvary. Things changed through the shed blood of Christ for us.
In addition to the above comment, this question (or questions similar to it) have been asked and addressed on multiple previous occasions on the eBible.com website, as indicated by the questions listed to the lower right of this latest question. These questions have included:
What does it mean when Jesus says "my yoke is easy and my burden is light" (Matthew 11:30)?
What did Jesus mean when He said, "Take up your cross and follow Me" (Matthew 16:24; Mark 8:34; Luke 9:23)?
What did Jesus mean by "My burden is ‘light’”?
Why did Jesus tell people to take up the cross, and what does it mean?